Trimethoprim 200mg Tablets

Trimethoprim is an antibiotic commonly used to treat urinary tract infections (UTIs), including cystitis in women. It works by targeting and eliminating bacteria responsible for the infection.

Trimethoprim functions by blocking the bacteria’s ability to produce folic acid, an essential component for bacterial growth and replication. By interfering with this process, trimethoprim halts bacterial multiplication, allowing the body’s immune system to clear the infection. Most women experience symptom relief within 24 hours, with full recovery expected within three days of treatment.

• The usual dose for treating cystitis in women is 200mg twice daily for three days (one tablet every 12 hours).
• Tablets should be swallowed whole with a glass of water and not chewed.
• It is best to take the medicine at the same times each day to maintain effectiveness.
• Completing the full three-day course is essential, even if symptoms improve earlier, to prevent reinfection and antibiotic resistance.

Most people tolerate trimethoprim well, but some may experience mild side effects. These include:

• Common side effects (up to 1 in 10 people):

  • Nausea or vomiting.
  • Diarrhoea.
  • Headache.
  • Skin rashes or itching.
  • Sore mouth or oral thrush.

• Rare but serious side effects:

  • Severe allergic reactions (angioedema or anaphylaxis) – Seek urgent medical attention if you experience swelling of the face, lips, or throat, difficulty breathing, or a rash spreading across the body.
  • Severe skin reactions – Stop taking the medication if you develop blistering, peeling skin, or painful sores.
  • Blood disorders – Symptoms such as persistent sore throat, unusual bruising, or extreme tiredness should be reported to a doctor immediately.

If any side effects become severe or persistent, seek medical advice.

Trimethoprim is not suitable for everyone, and some individuals may require an alternative treatment.

Do NOT take Trimethoprim if you:

• Are allergic to trimethoprim or any of its ingredients.
• Are pregnant or trying to conceive (it can affect folic acid levels).
• Have severe liver disease.

Check with a doctor or pharmacist before taking Trimethoprim if you:

• Have kidney problems or are on dialysis.
• Have low folic acid levels, which can cause anaemia.
• Are at risk of high potassium levels.
• Have porphyria, a rare metabolic disorder.

Potential Drug Interactions:

Trimethoprim can interact with certain medications, including:

• Diabetes medication (repaglinide).
• Heart medicines (procainamide, digoxin).
• Diuretics (water tablets).
• Warfarin and blood thinners.
• Methotrexate and other immunosuppressants.

Always inform your doctor or pharmacist about any other medications you are taking.

While antibiotics are effective, some lifestyle adjustments can aid recovery and prevent future infections:

• Increase fluid intake to 2-3 litres per day to help flush bacteria from the bladder.
• Avoid caffeine, alcohol, and fizzy drinks, as these can irritate the bladder.
• Take pain relief such as paracetamol or ibuprofen if needed.
• Consider a ‘wait-and-see’ approach – Mild cases of cystitis may resolve on their own within a few days without antibiotics.

For recurrent infections, consult a doctor for further investigation or alternative treatments.