Rifaximin (Xifaxanta)

Xifaxan is the brand name for the antibiotic rifaximin. It works locally in the intestines, with minimal absorption into the bloodstream, making it especially useful for digestive tract issues.

Xifaxan works by stopping the growth of specific bacteria in the intestines. This helps to reduce harmful bacterial activity, ease symptoms like diarrhoea and bloating, and restore balance to the gut environment.

Xifaxan is administered by mouth, with or without food. The dose and duration depend on the condition being treated. It’s important to follow your doctor’s instructions carefully and complete the full course to ensure the treatment is effective.

Many people start to notice an improvement within one to two days of starting Xifaxan, though it may take a few days for symptoms to fully settle. The response time can vary depending on the underlying condition.

No, Xifaxan is not effective for all types of diarrhoea. It is mainly used for cases caused by E. coli (such as travellers’ diarrhoea), for managing diarrhoea-predominant IBS, and to help prevent complications related to liver disease. It does not work for viral diarrhoea or infections caused by certain other bacteria.

Common side effects of Xifaxan may include:

• Feeling sick (nausea)

• Headache

• Wind (flatulence)

• Stomach discomfort or bloating

Serious side effects are uncommon, but allergic reactions or worsening symptoms should be reported to a healthcare professional promptly.

• Do not take Xifaxan if you are allergic to rifaximin or similar antibiotics (such as rifampicin).

• Inform your doctor if you have liver disease, as your dose may need to be adjusted.

• Xifaxan may not be suitable if the diarrhoea is caused by bacteria that are resistant to it.

• Let your doctor or pharmacist know about any other medicines or supplements you are taking to avoid possible interactions.