QUVIVIQ

QUVIVIQ (daridorexant) is a prescription medication specifically designed for adults suffering from insomnia - a sleep disorder characterized by difficulty falling asleep, staying asleep, or getting restorative sleep. It's approved for the treatment of adult patients whose insomnia symptoms have been present for at least 3 months and significantly impact daytime functioning.

Unlike traditional sleep medications that rely on sedation, QUVIVIQ works through a different mechanism:

• It targets and blocks the OX1R and OX2R orexin receptors in the brain
• Orexin is a neuropeptide responsible for regulating sleep-wake cycles
• By blocking these receptors, QUVIVIQ helps restore the natural sleep-wake cycle
• This approach enhances both sleep duration and quality
• Patients can fall asleep more naturally without heavy sedation
• This mechanism may result in less morning grogginess compared to sedative medications

Common side effects include:

• Headache
• Somnolence (drowsiness)

More serious side effects may include:

• Decreased awareness and alertness the morning after taking it
• Daytime sleepiness that may increase risk of falls
• Sleep paralysis (temporary inability to move or talk while falling asleep or waking up)
• Hallucinations during sleep-wake transitions
• Cataplexy-like symptoms (temporary weakness in legs)
• Complex sleep behaviors (sleepwalking, sleep-driving, eating, making calls, or having sex while not fully awake)
• Worsening depression and suicidal thoughts

Who Should Not Take QUVIVIQ:

• People with narcolepsy
• Those allergic to daridorexant or any ingredients in QUVIVIQ
• Patients using strong CYP3A4 inhibitors

Special Precautions:

• It's a federally controlled substance due to potential for abuse or dependence
• Do not take more than prescribed
• Take only if you can stay in bed for at least 7 hours
• Take within 30 minutes before bedtime
• Avoid alcohol while using QUVIVIQ
• Do not drive or operate machinery if you don't feel fully alert
• Use caution in elderly patients, especially those over 75
• Tell your healthcare provider about all medical conditions, particularly:
  • History of depression, mental illness, or suicidal thoughts
  • Drug or alcohol abuse
  • Lung or breathing problems including sleep apnea
  • Liver problems
  • Pregnancy or breastfeeding
• Do not take with other medicines that cause sleepiness unless instructed by your doctor
• Avoid grapefruit juice in the evening when taking QUVIVIQ

Always consult with your healthcare provider for personalized guidance on whether QUVIVIQ is appropriate for your specific situation.